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NFL Week 2 Odds, Expert Analysis & Must-Bet Games for 2024 Season


San Francisco 49ers tailback Christian McCaffrey missed the team’s first regular-season game on Monday due to calf and Achilles injuries. He will be available for the NFL Week 2?

Jordan Mason came on in his place and had 28 carries for 147 yards and a touchdown, his highest total of carries since high school.

It looks like the team’s running game is well in hand until McCaffrey returns, which is good – the main problem for McCaffrey is Achilles tendonitis, which can be a tricky injury.

The 49ers rolled over the New York Jets without McCaffrey and look like the team to beat in the NFC so far.

Dominate the Weekend Action: NFL Week 2 Odds and Predictions

 

Let’s look at some must-bet games from a sports betting perspective heading into Week 2.

 

Seattle Seahawks (-3) at New England Patriots (O/U 38)

When: Sunday, September 15, 1:00 pm ET, FOX

Seattle won their opener thanks to the defensive mindset of new head coach Mike Macdonald. You can say the same thing about the upset win the Pats picked up in Cincinnati behind Jerod Mayo. Seattle also got a big day out of tailback Kenneth Walker III, and Geno Smith looked more confident and polished at quarterback. The Patriots’ offense is very workmanlike with Jacoby Brissett running things, but their defense will keep them in this game.

NFL Pick: Patriots to cover.

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N.Y. Giants (+1.5) at Washington Commanders (O/U 44)

When: Sunday, September 15, 1:00 pm ET, FOX

Is it time for the Giants to move on from sixth-year quarterback Daniel Jones? After Week 1, all signs seem to be pointing to Yes, as he was badly out dueled by another long-time struggling quarterback in Sam Darnold last week. Washington got their offense going against Tampa Bay, but it was just too late to overcome the Buccaneers’ onslaught. Expect Jayden Daniels to show that second-half confidence from a week ago from the opening kickoff, and expect the Giants to struggle to move the ball again.

NFL Pick: Commanders to win and cover.

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Pittsburgh Steelers (-3) at Denver Broncos (O/U 36.5)

When: Sunday, September 15, 4:25 pm ET, CBS

Russell Wilson (calf) had to miss the season opener, and Justin Fields played reasonably well in his stead. The Pittsburgh defense is such that the team can win if the running game can pound out extended drives, and ball security is an offensive priority. The Steelers bring a physicality to the game that will intimidate rookie Bo Nix, who seems in a bit over his head as the starting quarterback of the Broncos.

NFL Pick: Steelers to win and cover.

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Chicago Bears (+7) at Houston Texans (O/U 45.5) SNF

When: Sunday Night Football, September 15, 8:20 pm ET, NBC

This battle of exciting young quarterbacks shows C.J. Stroud of the Texans to be well ahead of Caleb Williams of the Bears in terms of the NFL learning curve. Even so, the Bears’ defense and special teams picked Williams up and delivered a Week 1 over Tennessee. Williams missed several throws and executed poorly, but the shift in game speed from the Pac-12 to the NFL is significant. Both teams have excellent wide receiver groups, and both teams have stout defenses. The Texans have the edge at tailback with Joe Mixon and should be able to eke this out, but can they win by a touchdown?

NFL Pick: Bears to cover.

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Atlanta Falcons (+6.5) at Philadelphia Eagles (O/U 47) MNF

When: Monday Night Football, September 16, 8:15 pm ET, ESPN/ABC

The Pittsburgh Steelers were able to befuddle new Atlanta Falcons quarterback Kirk Cousins with a variety of coverage and pressure looks, so expect Philadelphia DC Vic Fangio to use a similar approach. The Falcons should be more used to their new starting quarterback and have better synergy, but the Eagles are one of the toughest defenses in the league.

NFL Pick: Eagles to win and cover.

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